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dc.contributor.authorOkunlola, A.-
dc.date.accessioned2018-10-22T10:44:52Z-
dc.date.available2018-10-22T10:44:52Z-
dc.date.issued2016-
dc.identifier.issn0189-8434-
dc.identifier.otherui_art_okunlola_optimization_2016-
dc.identifier.otherNigerian Journal of Pharmaceutical Research 12(1), pp. 49-58-
dc.identifier.urihttp://ir.library.ui.edu.ng/handle/123456789/3458-
dc.description.abstractBackground: Release-retarding polymers in matrix tablets play a vital role in controlling drug release from tablets. Objectives: To prepare metoprolol succinate tablets by direct compression using Ofada rice (Oryza glaberrima Steud) starch acetate, degree of substitution (DS) 2.22, as a matrix for sustained release. Materials and methods: The central composite design and response surface methodology were applied to evaluate the interactive effects of three variables: percent content of starch acetate (X1), compression pressure (X2) and compression time (X3), on tablet crushing strength, friability and dissolution time (t80). Results: Crushing strength was 90.0 to 140.50 N; Friability 0.05 to 0.90% and t80 5.75 to 11.50 h. X1 and X2 had significant effects on crushing strength and dissolution time (p < 0.0001). The interactions between X1 and X2 and those between X1 and X3 were significant on crushing strength and dissolution time, and on friability respectively (p < 0.0001). The correlation coefficients indicated that the regression model represented the experimental data well (R2 = 0.9971 and R2 (Adj) = 0.9944 for crushing strength; R2 = 0.9976 and R2 (Adj) = 0.9954 for friability; R2 = 0.9979 and R2 (Adj) = 0.9961 for t80). Optimized conditions for formulation of metoprolol succinate tablets were 60 %w/w Ofada starch acetate; 150 MNm-2 compression pressure and 60s compression time. Conclusion: Optimized formulations of metoprolol tablets containing Ofada starch acetate with good mechanical strength and prolonged dissolution can be obtained when process conditions are adjusted within the reported values.en_US
dc.language.isoenen_US
dc.publisherPharmaceutical Society of Nigeriaen_US
dc.subjectCentral composite designen_US
dc.subjectMetoprolol succinate tabletsen_US
dc.subjectOfada rice starch acetateen_US
dc.subjectResponse surface methodologyen_US
dc.titleOptimization of formulations of metoprolol succinate tablets containing ofada rice starch acetate as tablet matrix for sustained release using response surface methodologyen_US
dc.typeArticleen_US
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