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DC Field | Value | Language |
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dc.contributor.author | Kooffreh, M. E. | - |
dc.contributor.author | Anumudu, C. I. | - |
dc.contributor.author | Kumar, P. L. | - |
dc.date.accessioned | 2018-10-08T13:55:18Z | - |
dc.date.available | 2018-10-08T13:55:18Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2314-8667||2314-8675 | - |
dc.identifier.other | Advanced Biomedical Research 3(118), pp. 1-6 | - |
dc.identifier.other | ui_art_kooffreh_insertion_2014 | - |
dc.identifier.uri | http://ir.library.ui.edu.ng/handle/123456789/1130 | - |
dc.description.abstract | Background: Hypertension is a public health challenge due to its high prevalence, and is a major risk factor for cardiovascular diseases. This study was designed to determine the frequency of the I/D polymorphism of the angiotensin-converting enzyme gene and its association with hypertension in a sample population of Calabar and Uyo, South-South Nigeria. Materials and Methods: A population-based case control design consisting of total of 1224 participants, 612 each of patients and controls, were randomly recruited from hypertension clinics and the general population. The I/D polymorphism was investigated using polymerase chain reaction. Multiple regression and odds ratio (OR) was applied to test whether the ID genotypes were predictors of hypertension. Results: The I/D genotype frequencies were 73(12%), 262(43%) and 277(45%); 74(12%), 303(50%) and 235(38%) for the II, ID, DD genotype in patient and control groups, respectively. A higher frequency of the ID genotype was observed in controls of which 208(61%) were females. By multiple regression analysis, age was a predictor for SBP in patients, r = 0.596, and DBP in controls, r = 0.555. Gender, Body mass index, I/D genotypes were not significant predictors for hypertension but the I/D polymorpism was associated with an increased risk for hypertension with an OR of 1.15 95%CI (0.924-1.456). Conclusion: The I/D polymorphism of the angiotensin-converting enzyme gene was a risk factor for hypertension in the sample population of Calabar and Uyo. This research will form baseline information for subsequent molecular studies in this population. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Medknow Publications | en_US |
dc.title | Insertion/deletion polymorphism of the angiotensin-converting enzyme gene and the risk of hypertension among residents of two cities, South-South Nigeria | en_US |
dc.type | Article | en_US |
Appears in Collections: | Scholarly works |
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(43) ui_art_kooffreh_insertion_2014.pdf | 790.24 kB | Adobe PDF | View/Open |
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