Please use this identifier to cite or link to this item:
http://ir.library.ui.edu.ng/handle/123456789/1137
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Onyegbula, K. | - |
dc.contributor.author | Onile, O. S. | - |
dc.contributor.author | Okoje, V. N. | - |
dc.contributor.author | Anumudu, C. I. | - |
dc.date.accessioned | 2018-10-08T14:04:19Z | - |
dc.date.available | 2018-10-08T14:04:19Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1965-0817 ||1965-0825 | - |
dc.identifier.other | Journal of African Cancer 7, pp. 16-21 | - |
dc.identifier.other | ui_art_onyegbula_development_2015 | - |
dc.identifier.uri | http://ir.library.ui.edu.ng/handle/123456789/1137 | - |
dc.description.abstract | Context: This study investigated the presence or absence of β-catenin and Patched1 (PTCH1) genes involved in the developmental pathway in ameloblastoma, in order to clarify the genetic etiology of this tumor. Aim: The aim of this study was to investigate whether PTCH1 and β-catenin genes are involved in the development of ameloblastoma. Subjects and Methods: Archived formalin-fixed paraffin-embedded specimens of 89 ameloblastoma cases from the year 2000 to 2010 were genotyped by polymerase chain reaction (PCR). Results: A total of 21 (23.6%) of the 89 ameloblastoma cases were positive for β-catenin gene, where 14/21 (66.7%) cases were mandibular ameloblastoma. Plexiform 5/21 (23.8%) and cystic 5/21 (23.8%) ameloblastoma were the most regular histological type positive for β-catenin. However, β-catenin positive was more in the feminine gender (11/19, 57.9%) than the masculine (8/19, 42.1%). Only one case was positive for PTCH1 gene and this was histologically a mandibular site and plexiform-type ameloblastoma. Conclusions: This study suggested that β-catenin and PTCH1 genes may play an important role in the pathogenesis of ameloblastoma. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.title | Developmental signaling genes in ameloblastoma | en_US |
dc.type | Article | en_US |
Appears in Collections: | Scholarly works |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
(46) ui_art_onyegbula_development_2015.pdf | 907.25 kB | Adobe PDF | View/Open |
Items in UISpace are protected by copyright, with all rights reserved, unless otherwise indicated.