Please use this identifier to cite or link to this item: http://ir.library.ui.edu.ng/handle/123456789/1137
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dc.contributor.authorOnyegbula, K.-
dc.contributor.authorOnile, O. S.-
dc.contributor.authorOkoje, V. N.-
dc.contributor.authorAnumudu, C. I.-
dc.date.accessioned2018-10-08T14:04:19Z-
dc.date.available2018-10-08T14:04:19Z-
dc.date.issued2015-
dc.identifier.issn1965-0817 ||1965-0825-
dc.identifier.otherJournal of African Cancer 7, pp. 16-21-
dc.identifier.otherui_art_onyegbula_development_2015-
dc.identifier.urihttp://ir.library.ui.edu.ng/handle/123456789/1137-
dc.description.abstractContext: This study investigated the presence or absence of β-catenin and Patched1 (PTCH1) genes involved in the developmental pathway in ameloblastoma, in order to clarify the genetic etiology of this tumor. Aim: The aim of this study was to investigate whether PTCH1 and β-catenin genes are involved in the development of ameloblastoma. Subjects and Methods: Archived formalin-fixed paraffin-embedded specimens of 89 ameloblastoma cases from the year 2000 to 2010 were genotyped by polymerase chain reaction (PCR). Results: A total of 21 (23.6%) of the 89 ameloblastoma cases were positive for β-catenin gene, where 14/21 (66.7%) cases were mandibular ameloblastoma. Plexiform 5/21 (23.8%) and cystic 5/21 (23.8%) ameloblastoma were the most regular histological type positive for β-catenin. However, β-catenin positive was more in the feminine gender (11/19, 57.9%) than the masculine (8/19, 42.1%). Only one case was positive for PTCH1 gene and this was histologically a mandibular site and plexiform-type ameloblastoma. Conclusions: This study suggested that β-catenin and PTCH1 genes may play an important role in the pathogenesis of ameloblastoma.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.titleDevelopmental signaling genes in ameloblastomaen_US
dc.typeArticleen_US
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