Please use this identifier to cite or link to this item:
http://ir.library.ui.edu.ng/handle/123456789/1137
Title: | Developmental signaling genes in ameloblastoma |
Authors: | Onyegbula, K. Onile, O. S. Okoje, V. N. Anumudu, C. I. |
Issue Date: | 2015 |
Publisher: | Springer |
Abstract: | Context: This study investigated the presence or absence of β-catenin and Patched1 (PTCH1) genes involved in the developmental pathway in ameloblastoma, in order to clarify the genetic etiology of this tumor. Aim: The aim of this study was to investigate whether PTCH1 and β-catenin genes are involved in the development of ameloblastoma. Subjects and Methods: Archived formalin-fixed paraffin-embedded specimens of 89 ameloblastoma cases from the year 2000 to 2010 were genotyped by polymerase chain reaction (PCR). Results: A total of 21 (23.6%) of the 89 ameloblastoma cases were positive for β-catenin gene, where 14/21 (66.7%) cases were mandibular ameloblastoma. Plexiform 5/21 (23.8%) and cystic 5/21 (23.8%) ameloblastoma were the most regular histological type positive for β-catenin. However, β-catenin positive was more in the feminine gender (11/19, 57.9%) than the masculine (8/19, 42.1%). Only one case was positive for PTCH1 gene and this was histologically a mandibular site and plexiform-type ameloblastoma. Conclusions: This study suggested that β-catenin and PTCH1 genes may play an important role in the pathogenesis of ameloblastoma. |
URI: | http://ir.library.ui.edu.ng/handle/123456789/1137 |
ISSN: | 1965-0817 ||1965-0825 |
Appears in Collections: | Scholarly works |
Files in This Item:
File | Description | Size | Format | |
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(46) ui_art_onyegbula_development_2015.pdf | 907.25 kB | Adobe PDF | View/Open |
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