Please use this identifier to cite or link to this item:
http://ir.library.ui.edu.ng/handle/123456789/2295
Title: | Respiratory syncytial virus infection: denominator-based studies in Indonesia, Mozambique, Nigeria and South Africa |
Authors: | Robertson, S. E. Roca, A. Alonso, P. Simoes, E. A. F. Kartasasmita, C. B. Olaleye, D. O. Odaibo, G. N. Collinson, M. Venter, M. Zhu, Y. Wright, P. F. |
Issue Date: | 2004 |
Abstract: | OBJECTIVE:To assess the burden of respiratory syncytial virus (RSV)-associated lower respiratory infections (LRI) in children in four developing countries.METHODS:A WHO protocol for prospective population-based surveillance of acute respiratory infections in children aged less than 5 years was used at sites in Indonesia, Mozambique, Nigeria and South Africa. RSV antigen was identified by enzyme-linked immunosorbent assay performed on nasopharyngeal specimens from children meeting clinical case definitions.FINDINGS:Among children aged < 5 years, the incidence of RSV-associated LRI per 1000 child-years was 34 in Indonesia and 94 in Nigeria. The incidence of RSV-associated severe LRI per 1000 child-years was 5 in Mozambique, 10 in Indonesia, and 9 in South Africa. At all study sites, the majority of RSV cases occurred in infants.CONCLUSION:These studies demonstrate that RSV contributes to a substantial but quite variable burden of LRI in children aged < 5 years in four developing countries. The possible explanations for this variation include social factors, such as family size and patterns of seeking health care; the proportion of children infected by human immunodeficiency syndrome (HIV); and differences in clinical definitions used for obtaining samples. The age distribution of cases indicates the need for an RSV vaccine that can protect children early in life. |
URI: | http://ir.library.ui.edu.ng/handle/123456789/2295 |
Appears in Collections: | scholarly works |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
(22)ui_bull_robertson_respiratory_2004.pdf | 604.54 kB | Adobe PDF | View/Open |
Items in UISpace are protected by copyright, with all rights reserved, unless otherwise indicated.