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DC Field | Value | Language |
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dc.contributor.author | Robertson, S. E. | - |
dc.contributor.author | Roca, A. | - |
dc.contributor.author | Alonso, P. | - |
dc.contributor.author | Simoes, E. A. F. | - |
dc.contributor.author | Kartasasmita, C. B. | - |
dc.contributor.author | Olaleye, D. O. | - |
dc.contributor.author | Odaibo, G. N. | - |
dc.contributor.author | Collinson, M. | - |
dc.contributor.author | Venter, M. | - |
dc.contributor.author | Zhu, Y. | - |
dc.contributor.author | Wright, P. F. | - |
dc.date.accessioned | 2018-10-12T12:35:46Z | - |
dc.date.available | 2018-10-12T12:35:46Z | - |
dc.date.issued | 2004 | - |
dc.identifier.other | Bulletin of the World Health Organization 82(12) pp.914-922 | - |
dc.identifier.uri | http://ir.library.ui.edu.ng/handle/123456789/2295 | - |
dc.description.abstract | OBJECTIVE:To assess the burden of respiratory syncytial virus (RSV)-associated lower respiratory infections (LRI) in children in four developing countries.METHODS:A WHO protocol for prospective population-based surveillance of acute respiratory infections in children aged less than 5 years was used at sites in Indonesia, Mozambique, Nigeria and South Africa. RSV antigen was identified by enzyme-linked immunosorbent assay performed on nasopharyngeal specimens from children meeting clinical case definitions.FINDINGS:Among children aged < 5 years, the incidence of RSV-associated LRI per 1000 child-years was 34 in Indonesia and 94 in Nigeria. The incidence of RSV-associated severe LRI per 1000 child-years was 5 in Mozambique, 10 in Indonesia, and 9 in South Africa. At all study sites, the majority of RSV cases occurred in infants.CONCLUSION:These studies demonstrate that RSV contributes to a substantial but quite variable burden of LRI in children aged < 5 years in four developing countries. The possible explanations for this variation include social factors, such as family size and patterns of seeking health care; the proportion of children infected by human immunodeficiency syndrome (HIV); and differences in clinical definitions used for obtaining samples. The age distribution of cases indicates the need for an RSV vaccine that can protect children early in life. | en_US |
dc.language.iso | en | en_US |
dc.title | Respiratory syncytial virus infection: denominator-based studies in Indonesia, Mozambique, Nigeria and South Africa | en_US |
dc.type | Article | en_US |
Appears in Collections: | scholarly works |
Files in This Item:
File | Description | Size | Format | |
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(22)ui_bull_robertson_respiratory_2004.pdf | 604.54 kB | Adobe PDF | View/Open |
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