Please use this identifier to cite or link to this item: http://ir.library.ui.edu.ng/handle/123456789/2295
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dc.contributor.authorRobertson, S. E.-
dc.contributor.authorRoca, A.-
dc.contributor.authorAlonso, P.-
dc.contributor.authorSimoes, E. A. F.-
dc.contributor.authorKartasasmita, C. B.-
dc.contributor.authorOlaleye, D. O.-
dc.contributor.authorOdaibo, G. N.-
dc.contributor.authorCollinson, M.-
dc.contributor.authorVenter, M.-
dc.contributor.authorZhu, Y.-
dc.contributor.authorWright, P. F.-
dc.date.accessioned2018-10-12T12:35:46Z-
dc.date.available2018-10-12T12:35:46Z-
dc.date.issued2004-
dc.identifier.otherBulletin of the World Health Organization 82(12) pp.914-922-
dc.identifier.urihttp://ir.library.ui.edu.ng/handle/123456789/2295-
dc.description.abstractOBJECTIVE:To assess the burden of respiratory syncytial virus (RSV)-associated lower respiratory infections (LRI) in children in four developing countries.METHODS:A WHO protocol for prospective population-based surveillance of acute respiratory infections in children aged less than 5 years was used at sites in Indonesia, Mozambique, Nigeria and South Africa. RSV antigen was identified by enzyme-linked immunosorbent assay performed on nasopharyngeal specimens from children meeting clinical case definitions.FINDINGS:Among children aged < 5 years, the incidence of RSV-associated LRI per 1000 child-years was 34 in Indonesia and 94 in Nigeria. The incidence of RSV-associated severe LRI per 1000 child-years was 5 in Mozambique, 10 in Indonesia, and 9 in South Africa. At all study sites, the majority of RSV cases occurred in infants.CONCLUSION:These studies demonstrate that RSV contributes to a substantial but quite variable burden of LRI in children aged < 5 years in four developing countries. The possible explanations for this variation include social factors, such as family size and patterns of seeking health care; the proportion of children infected by human immunodeficiency syndrome (HIV); and differences in clinical definitions used for obtaining samples. The age distribution of cases indicates the need for an RSV vaccine that can protect children early in life.en_US
dc.language.isoenen_US
dc.titleRespiratory syncytial virus infection: denominator-based studies in Indonesia, Mozambique, Nigeria and South Africaen_US
dc.typeArticleen_US
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