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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Olugbuyiro, J. A. O. | - |
dc.contributor.author | Moody, J. O. | - |
dc.contributor.author | Hamann, M. T. | - |
dc.date.accessioned | 2018-10-17T12:38:12Z | - |
dc.date.available | 2018-10-17T12:38:12Z | - |
dc.date.issued | 2013-01 | - |
dc.identifier.issn | 1119-5096 | - |
dc.identifier.other | African Journal Biomedical Research 16(1), pp. 19- 24 | - |
dc.identifier.other | ui_art_olugbuyiro_Phytosterols_2013 | - |
dc.identifier.uri | http://ir.library.ui.edu.ng/handle/123456789/2995 | - |
dc.description.abstract | The growing problems of tuberculosis have led to the search for new anti-Mtb agents from higher plants. The stem bark of Spondias mombin was evaluated for its in vitro activity against Mycobacterium tuberculosis (H37Rv strain). Bioassay-guided fractionation of the methanol extract was carried out by Vacuum Liquid Chromatography (VLC) on Silica gel (230-400 mesh) and purification was done using HPLC and TLC. In vitro antimycobacterial susceptibility was performed by a fluorometric microplate alamar blue assay (MABA) and percentage mycobacterial inhibition was calculated. The structures of the isolated compounds were established by spectroscopic analysis. The active VLC fraction exhibited 91% inhibition against M. tuberculosis H37Rv at a concentration of 40 μg/mL. The HPLC fraction SMi-15 containing compounds 1 and 2 showed 92.8% inhibition against M. tuberculosis. Two new antimycobacterial phytosterols were isolated from the stem bark of S. mombin and the structureswere identified as mombintane I (1) and mombintane II (2). The stem bark extractives of S. mombin contain antitubercular principles of the class phytosterol and support an important potential of triterpenoids. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Spondias mombin | en_US |
dc.subject | mycobacterium tuberculosis | en_US |
dc.subject | antimycobacterial | en_US |
dc.subject | mombintane I | en_US |
dc.subject | mombintane II | en_US |
dc.title | Phytosterols from spondias mombin Linn with antimycobacterial activities | en_US |
dc.type | Article | en_US |
Appears in Collections: | scholarly works |
Files in This Item:
File | Description | Size | Format | |
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[21]Phytosterols from Spondias mombin Linn with Antimycobacterial Activities.pdf | 678.81 kB | Adobe PDF | View/Open |
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