Please use this identifier to cite or link to this item: http://ir.library.ui.edu.ng/handle/123456789/2995
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dc.contributor.authorOlugbuyiro, J. A. O.-
dc.contributor.authorMoody, J. O.-
dc.contributor.authorHamann, M. T.-
dc.date.accessioned2018-10-17T12:38:12Z-
dc.date.available2018-10-17T12:38:12Z-
dc.date.issued2013-01-
dc.identifier.issn1119-5096-
dc.identifier.otherAfrican Journal Biomedical Research 16(1), pp. 19- 24-
dc.identifier.otherui_art_olugbuyiro_Phytosterols_2013-
dc.identifier.urihttp://ir.library.ui.edu.ng/handle/123456789/2995-
dc.description.abstractThe growing problems of tuberculosis have led to the search for new anti-Mtb agents from higher plants. The stem bark of Spondias mombin was evaluated for its in vitro activity against Mycobacterium tuberculosis (H37Rv strain). Bioassay-guided fractionation of the methanol extract was carried out by Vacuum Liquid Chromatography (VLC) on Silica gel (230-400 mesh) and purification was done using HPLC and TLC. In vitro antimycobacterial susceptibility was performed by a fluorometric microplate alamar blue assay (MABA) and percentage mycobacterial inhibition was calculated. The structures of the isolated compounds were established by spectroscopic analysis. The active VLC fraction exhibited 91% inhibition against M. tuberculosis H37Rv at a concentration of 40 μg/mL. The HPLC fraction SMi-15 containing compounds 1 and 2 showed 92.8% inhibition against M. tuberculosis. Two new antimycobacterial phytosterols were isolated from the stem bark of S. mombin and the structureswere identified as mombintane I (1) and mombintane II (2). The stem bark extractives of S. mombin contain antitubercular principles of the class phytosterol and support an important potential of triterpenoids.en_US
dc.language.isoen_USen_US
dc.subjectSpondias mombinen_US
dc.subjectmycobacterium tuberculosisen_US
dc.subjectantimycobacterialen_US
dc.subjectmombintane Ien_US
dc.subjectmombintane IIen_US
dc.titlePhytosterols from spondias mombin Linn with antimycobacterial activitiesen_US
dc.typeArticleen_US
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