Please use this identifier to cite or link to this item: http://ir.library.ui.edu.ng/handle/123456789/3456
Full metadata record
DC FieldValueLanguage
dc.contributor.authorOkunlola, A.-
dc.contributor.authorOgunkoya, T. O.-
dc.date.accessioned2018-10-22T10:34:51Z-
dc.date.available2018-10-22T10:34:51Z-
dc.date.issued2015-
dc.identifier.issn0189-8434-
dc.identifier.otherui_art_okunlola_acetylated_2015-
dc.identifier.otherNigerian Journal of Pharmaceutical Research 11(1), pp. 1-12-
dc.identifier.urihttp://ir.library.ui.edu.ng/handle/123456789/3456-
dc.description.abstractBackground: Acetylated starches with degrees of substitution (DS) of > 2 have been found suitable for sustained release applications because of their hydrophobic nature and thermoplasticity. The short half-life and high dosing frequency of repaglinide make it an ideal candidate for sustained release. Objectives: To formulate and evaluate repaglinide microspheres using acetylated starch of the indigenous rice species Oryza glaberrima Steud (Ofada) as polymer. Materials and Methods: Ofada rice starch was acetylated with acetic anhydride in pyridine (DS 2.68) and characterized for morphology (Scanning electron microscope, SEM), Crystallinity (Fourier Transform Infra-Red spectroscopy, FTIR, and X-ray diffraction crystallography, XRD), density and swelling. Microspheres of repaglinide were prepared by emulsification solvent-evaporation method, varying the drug-polymer ratio (1:2, 1:4, 1:8 and 1:10) and polymer type (ethyl cellulose as standard). Microspheres were characterized for particle size, wall thickness, swelling, entrapment efficiency, time taken for 80% drug release (t80) and permeability. Data obtained from in-vitro drug release studies were fitted to various kinetic models. Results: Repaglinide microspheres were near spherical, discrete and of size range 23.45 ± 4.25 to 44.55±3.85 μm. FTIR spectra revealed the absence of drug–polymer interaction and complete drug entrapment. Particle size, swelling, entrapment and wall thickness increased with drug: polymer ratio and were generally higher in microspheres containing acetylated Ofada rice starch while t80 (195±6.60 - 395± 24.75 min) was lower. Drug release fitted the Hixson-Crowell kinetic model. Conclusions: The acetylated starch of Ofada rice was found suitable as a polymer to sustain the release of repaglinide in microsphere formulations.en_US
dc.language.isoenen_US
dc.publisherPharmaceutical Society of Nigeriaen_US
dc.subjectAcetylationen_US
dc.subjectOfada rice starchen_US
dc.subjectRepaglinideen_US
dc.subjectMicrosphereen_US
dc.subjectSustained releaseen_US
dc.titleAcetylated starch of ofada rice as a sustained release polymer in microsphere formulations of repaglinideen_US
dc.typeArticleen_US
Appears in Collections:scholarly works

Files in This Item:
File Description SizeFormat 
(16)ui_art_okunlola_acetylated_2015.pdf1.15 MBAdobe PDFThumbnail
View/Open


Items in UISpace are protected by copyright, with all rights reserved, unless otherwise indicated.