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Title: | Testicular and epididymal parameters of spondias mombin L. (anacardiaceae) protected male wistar rats exposed to sodium arsenite |
Authors: | Ola-Davies, O. Ajani, O. S. Oyeyemi, M. O. Ekundayo, S. |
Keywords: | Spondias mombin Wistar Rats Testicular Parameters Epididymal Parameters |
Issue Date: | 2014 |
Publisher: | IDOSI Publications |
Abstract: | The testicular and epididymal protective potential of Spondias mombin. L in arsenic-treated rats was carried out. Thirty-five male albino rats (225-228g) were used and grouped into 7 (A to G), each group containing 5 rats. Group A was treated with 0.1ml Dimethysulphoxide (DMSO), B (0.1ml of Distilled water), C (Sodium arsenite; SA-2.5mg/kg body weight), D (Ethylacetate fraction), E (Ethylacetate fraction for 7 days and Sodium arsenite the 7th day), F (Methanolic fraction for 7days and Sodium arsenite the 7th day) and G (Methanolic fraction for 7 days). The results showed significant decrease (P>0.05) in the mean value of both the right and left testes length for group C (treated with Sodium arsenite only) compared to the remaining groups. It was also observed that Group G (treated with Methanolic fraction) had the lowest mean value (P>0.05) for the left and right testes weight and the left and right testicular diameter when compared to other groups. It was also observed that Group G (treated with Methanolic fraction) had the lowest mean values for all the epididymal parameters in this study. There was a significant decrease in the mean value of left epididymal weight, right and left epididymal length of group G compared to group B (treated with distilled water) and group A (treated with DMSO). It was concluded that the Methanolic fraction of Spondias mombin. L has no protective effect on the male albino rats exposed to sodium arsenite as it caused a reduction in epididymal parameters and testicular weight and diameter which may trigger testicular degeneration leading to infertility. |
URI: | http://ir.library.ui.edu.ng/handle/123456789/5398 |
ISSN: | 1992-6197 |
Appears in Collections: | scholarly works |
Files in This Item:
File | Description | Size | Format | |
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(26)ui_art_ola-davies_testicular_2014.pdf | 544.37 kB | Adobe PDF | View/Open |
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